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Article

Probing the role of backbone hydrogen bonding in a critical beta sheet of the extracellular domain of a cys-loop receptor.

Chembiochem : a European journal of chemical biology - 25 May 2009

Gleitsman Kristin R, Lester Henry A, Dougherty Dennis A

Abstract excerpt

Probing the sheet: The network of hydrogen bonds formed in the outer beta sheet of the nicotinic acetylcholine receptor (nAChR; see figure) is fairly robust and tolerates single amide-to-ester mutations throughout. However, eliminating two proximal hydrogen bonds completely destroys receptor function; this adds further support to gating models that ascribe important roles to these beta strands of the nAChR...

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Identifiers

PMID: 19405066
DOI: 10.1002/cbic.200900092
PMCID: PMC2789490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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