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Article

Intra-subunit flexibility underlies activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.

Neuropharmacology - 1 Apr 2014

Chrisman Paul A, Podair Julie I, Jobe Emily M, Levandoski Mark M

Abstract excerpt

Allosteric modulation is a general feature of nicotinic acetylcholine receptors, yet the structural components and movements important for conversions among functional states are not well understood. In this study, we examine the communication between the binding sites for agonist and the modulator morantel (Mor) of neuronal α3β2 receptors, measuring evoked currents of receptors expressed in Xenopus oocytes with...

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Source

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Identifiers

PMID: 24373904
DOI: 10.1016/j.neuropharm.2013.12.017
PMCID: PMC3970552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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