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Article

The substituted-cysteine accessibility method (SCAM) to elucidate membrane protein structure.

Current protocols in neuroscience - 1 May 2001

Liapakis G, Simpson M M, Javitch J A

Abstract excerpt

The substituted-cysteine accessibility method (SCAM) provides an approach to identifying the residues in the membrane-spanning segments that line a channel, transporter, or binding-site crevice. SCAM can also be used to determine differences in the structures of the membrane-spanning segments in different functional states of the proteins, to map electrostatic potential in the membrane-spanning domains, and to...

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Identifiers

PMID: 18428478
DOI: 10.1002/0471142301.ns0415s08

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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