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Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice

14 Jan 2020

Abstract excerpt

Tau dysfunction is common in several neurodegenerative diseases including Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Affective symptoms have often been associated with aberrant tau pathology and are commonly comorbid in patients with tauopathies, indicating a connection between tau functioning and mechanisms of depression. The current study investigated depression-like behavior in Mapt−/− mice,...

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PMID: 31947657
DOI: 10.3390/cells9010210

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