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Article

Lithium improves hippocampal neurogenesis, neuropathology and cognitive functions in APP mutant mice.

PloS one - 20 Dec 2010

Fiorentini Anna, Rosi Maria Cristina, Grossi Cristina, Luccarini Ilaria, Casamenti Fiorella

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive deterioration of cognitive functions, extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles within neocortex and hippocampus. Adult hippocampal neurogenesis plays an important role in learning and memory processes and its abnormal regulation might account for cognitive impairments associated...

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Source

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Identifiers

PMID: 21187954
DOI: 10.1371/journal.pone.0014382
PMCID: PMC3004858

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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