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Article

Anti-aggregant tau mutant promotes neurogenesis

1 Dec 2017

Abstract excerpt

The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggregation and pronounced neuronal loss in the hippocampus whereas the anti-aggregant form has no deleterious effects. These two proteins differ mainly in their propensity to form ß structure and hence to...

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PMID: 29202785
DOI: 10.1186/s13024-017-0230-8

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