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Article

Impairments in neurogenesis are not tightly linked to depressive behavior in a transgenic mouse model of Alzheimer's disease.

PloS one - 1 Jan 2013

Iascone Daniel M, Padidam Sneha, Pyfer Mark S, Zhang Xiaohong, Zhao Lijuan, Chin Jeannie

Abstract excerpt

Alzheimer's disease (AD), the most common cause of dementia, is also associated with depression. Although the precise mechanisms that lead to depression in AD are unknown, the impairments in adult hippocampal neurogenesis observed in AD may play a role. Adult-born neurons play a critical role in regulating both cognition and mood, and reduced hippocampal neurogenesis is associated with depression in other...

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PMID: 24244537
DOI: 10.1371/journal.pone.0079651
PMCID: PMC3828273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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