Article
Neurogenesis and cell cycle-reactivated neuronal death during pathogenic tau aggregation.
Genes, brain, and behavior - 1 Feb 2008
Schindowski K, Belarbi K, Bretteville A, Ando K, Buée L
Abstract excerpt
The aim of the present study was to investigate the relation between neurogenesis, cell cycle reactivation and neuronal death during tau pathology in a novel tau transgenic mouse line THY-Tau22 with two frontotemporal dementia with parkinsonism linked to chromosome-17 mutations in a human tau isoform. This mouse displays all Alzheimer disease features of neurodegeneration and a broad timely resolution of tau...
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