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Article

A role for tau in learning, memory and synaptic plasticity

12 Feb 2018

Abstract excerpt

Abstract Tau plays a pivotal role in the pathogenesis of neurodegenerative disorders: mutations in the gene encoding for tau (MAPT) are linked to Fronto-temporal Dementia (FTD) and hyper-phosphorylated aggregates of tau forming neurofibrillary tangles (NFTs) that constitute a pathological hallmark of Alzheimer disease (AD) and FTD. Accordingly, tau is a favored therapeutic target for the treatment of these...

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PMID: 29453339
DOI: 10.1038/s41598-018-21596-3

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