Article
The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research.
Acta neuropathologica communications - 6 Jan 2021
Vandenabeele Marjan, Veys Lien, Lemmens Sophie, Hadoux Xavier, Gelders Géraldine, Masin Luca, Serneels Lutgarde, Theunis Jan, Saito Takashi, Saido Takaomi C, Jayapala Murali, De Boever Patrick, De Strooper Bart, Stalmans Ingeborg, van Wijngaarden Peter, Moons Lieve, De Groef Lies
Abstract excerpt
In this study, we report the results of a comprehensive phenotyping of the retina of the AppNL-G-F mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation by midlife. This rising Aβ burden coincides with local microglia reactivity, astrogliosis, and abnormalities in retinal vein morphology. Electrophysiological recordings...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.