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APP and its intracellular domain modulate Alzheimer’s disease risk gene networks in transgenic <i>APPsw</i> and <i>PSEN1M146I</i> porcine models

2024-03-22

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most frequent cause of dementia. The disease has a substantial genetic component comprising both highly penetrant familial mutations ( APP , PSEN1, and PSEN2 ) and sporadic cases with complex genetic etiology. Mutations in APP and PSEN1/2 alter the proteolytic processing of APP to its metabolites, including Aβ and APP Intracellular D...

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Literature Corpus work
9ad42d41-dd29-5b08-82b1-9a8964a45fcf
DOI
10.1101/2024.03.21.585176
Open publication

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APP and its intracellular domain modulate Alzheimer’s disease risk gene networks in transgenic <i>APPsw</i> and <i>PSEN1M146I</i> porcine modelsDOI 10.1101/2024.03.21.585176
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