Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s disease

31 May 2025

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, tau hyperphosphorylation, and neuroinflammation. The choroid plexus (ChP), serving as the blood-cerebrospinal fluid-brain barrier, plays essential roles in immune response to stress and brain homeostasis. However, the cellular and molecular contributions of the ChP to AD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Macrophage Migration Inhibitory Factor
Share to Memory and Neural Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40450296
DOI: 10.1186/s13024-025-00853-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s diseasePMID 40450296Read ↗

Multi-modal choroid plexus pathology in aging and Alzheimer’s diseaseSemantic proximity Read ↗

A Multi-omic Atlas of Human Choroid Plexus in Alzheimer’s DiseaseSemantic proximity Read ↗

Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasisSemantic proximity Read ↗

The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer’s diseaseSemantic proximity Read ↗

Mechanobiological Specialization of Choroid Plexus Macrophages Defined by Titin ExpressionSemantic proximity Read ↗

Ptpn20 maintains choroid plexus epithelial integrity to preserve amyloid-β homeostasis in Alzheimer's diseaseSemantic proximity Read ↗

A cellular and spatial map of the choroid plexus across brain ventricles and agesSemantic proximity Read ↗

Spatial and temporal transcriptomics reveal microglia-astroglia crosstalk in the amyloid-β plaque cell niche of Alzheimer’s diseaseSemantic proximity Read ↗

Single-cell and nucleus RNA-seq in a mouse model of AD reveal activation of distinct glial subpopulations in the presence of plaques and tanglesSemantic proximity Read ↗

Cell type-resolved proteomics reveals intra- and intercellular signaling in Alzheimer’s diseaseSemantic proximity Read ↗

Navigating the Molecular Maze of Alzheimer’s Disease: Developing A Human Hippocampal Atlas to Bridge Discovery and Clinical PracticeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.