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Article

Analysis of Pre- and Posttreatment Tissues from the SWOG S0800 Trial Reveals an Effect of Neoadjuvant Chemotherapy on the Breast Cancer Genome.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2020

Powles Ryan L, Wali Vikram B, Li Xiaotong, Barlow William E, Nahleh Zeina, Thompson Alastair M, Godwin Andrew K, Hatzis Christos, Pusztai Lajos

Abstract excerpt

PURPOSE: We performed whole-exome sequencing (WES) of pre- and posttreatment cancer tissues to assess the somatic mutation landscape of tumors before and after neoadjuvant taxane and anthracycline chemotherapy with or without bevacizumab. EXPERIMENTAL DESIGN: Twenty-nine pretreatment biopsies from the SWOG S0800 trial were subjected to WES to identify mutational patterns associated with response to neoadjuvant...

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Identifiers

PMID: 31919134
DOI: 10.1158/1078-0432.CCR-19-2405
PMCID: PMC7717064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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