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Unraveling breast cancer response to neoadjuvant chemotherapy through integrated genomic, transcriptomic, and circulating tumor DNA analysis.

Breast cancer research : BCR - 1 May 2025

Dong Menghao, Chen Jian, Lu Nannan, Wang Song, Wei Wenhui, Wang Ziming, Wang Jinnan, Zhang Jinguo, Han Xinghua, Wang Fufeng, Ou Qiuxiang, Bao Hua, Ma Xiaopeng, Shan Benjie, Pan Yueyin

Abstract excerpt

INTRODUCTION: Neoadjuvant chemotherapy (NAC) is a standard treatment for breast cancer (BC) to shrink tumors and facilitate surgery. However, the molecular underpinnings of response to NAC and prognosis have not been well characterized. METHODS: We enrolled 73 stage II/III BC patients who received NAC followed by surgery. Tumor tissue samples were available from 36 patients at baseline and 38 at the time of...

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Identifiers

PMID: 40312292
DOI: 10.1186/s13058-025-02026-5
PMCID: PMC12044986

Genes

DNHD1
NHSL1
PLEC
USH2A

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