Article
The Mutational Spectrum of Pre- and Post-Neoadjuvant Chemotherapy Triple-Negative Breast Cancers.
Genes - 23 Dec 2023
Aguilar-Mahecha Adriana, Alirezaie Najmeh, Lafleur Josiane, Bareke Eric, Przybytkowski Ewa, Lan Cathy, Cavallone Luca, Salem Myriam, Pelmus Manuela, Aleynikova Olga, Greenwood Celia, Lovato Amanda, Ferrario Cristiano, Boileau Jean-François, Mihalcioiu Catalin, Roy Josée-Anne, Marcus Elizabeth, Discepola Federico, Majewski Jacek, Basik Mark
Abstract excerpt
The response of triple-negative breast cancer (TNBC) patients to pre-operative (neoadjuvant chemotherapy) is a critical factor of their outcome. To determine the effects of chemotherapy on the tumor genome and to identify mutations associated with chemoresistance and sensitivity, we performed whole exome sequencing on pre/post-chemotherapy tumors and matched lymphocytes from 26 patients. We observed great...
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