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Comparative analysis of mutational patterns in triple negative breast cancer before and after neoadjuvant chemotherapy in patients with residual disease.

Gene - 15 Feb 2024

Singh Ashish, Georgy Josh Thomas, Dhananjayan Sakthi, Sigamani Elanthenral, John Ajoy Oommen, Joel Anjana, Chandramohan Jagan, Abarna Rajadurai, Rebekah Grace, Backianathan Selvamani, Abraham Deepak Thomas, Paul Mazhuvanchary Jacob, Chacko Raju Titus, Manipadam Marie Therese, Pai Rekha

Abstract excerpt

Triple-negative breast cancer (TNBC) is a heterogeneous disease with poor survival compared to other subtypes. Patients with residual disease after neoadjuvant chemotherapy (NAC) face an increased risk of relapse and death. We aimed to characterize the mutational landscape of this subset to offer insights into relapse pathogenesis and potential therapeutic targets. We retrospectively analyzed archived paired...

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Identifiers

PMID: 37951371
DOI: 10.1016/j.gene.2023.147980

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