Article
Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation.
Nature communications - 9 Nov 2016
Gellert Pascal, Segal Corrinne V, Gao Qiong, López-Knowles Elena, Martin Lesley-Ann, Dodson Andrew, Li Tiandao, Miller Christopher A, Lu Charles, Mardis Elaine R, Gillman Alexa, Morden James, Graf Manuela, Sidhu Kally, Evans Abigail, Shere Michael, Holcombe Christopher, McIntosh Stuart A, Bundred Nigel, Skene Anthony, Maxwell William, Robertson John, Bliss Judith M, Smith Ian, Dowsett Mitch
Abstract excerpt
Pre-surgical studies allow study of the relationship between mutations and response of oestrogen receptor-positive (ER+) breast cancer to aromatase inhibitors (AIs) but have been limited to small biopsies. Here in phase I of this study, we perform exome sequencing on baseline, surgical core-cuts and blood from 60 patients (40 AI treated, 20 controls). In poor responders (based on Ki67 change), we find...
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