Tumor Sequencing and Patient-Derived Xenografts in the Neoadjuvant Treatment of Breast Cancer.

doi:10.1093/jnci/djw306

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Article

Tumor Sequencing and Patient-Derived Xenografts in the Neoadjuvant Treatment of Breast Cancer.

Journal of the National Cancer Institute - 1 Jul 2017

Goetz Matthew P, Kalari Krishna R, Suman Vera J, Moyer Ann M, Yu Jia, Visscher Daniel W, Dockter Travis J, Vedell Peter T, Sinnwell Jason P, Tang Xiaojia, Thompson Kevin J, McLaughlin Sarah A, Moreno-Aspitia Alvaro, Copland John A, Northfelt Donald W, Gray Richard J, Hunt Katie, Conners Amy, Sicotte Hugues, Eckel-Passow Jeanette E, Kocher Jean-Pierre, Ingle James N, Ellingson Marissa S, McDonough Michelle, Wieben Eric D, Weinshilboum Richard, Wang Liewei, Boughey Judy C

Abstract excerpt

Background: Breast cancer patients with residual disease after neoadjuvant chemotherapy (NAC) have increased recurrence risk. Molecular characterization, knowledge of NAC response, and simultaneous generation of patient-derived xenografts (PDXs) may accelerate drug development. However, the feasibility of this approach is unknown. Methods: We conducted a prospective study of 140 breast cancer patients treated...

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PMID: 28376176
DOI: 10.1093/jnci/djw306
PMCID: PMC5408989

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