Article
Divergence of mutational signatures in association with breast cancer subtype.
Molecular carcinogenesis - 1 Nov 2022
Perry Gili, Dadiani Maya, Kahana-Edwin Smadar, Pavlovski Anya, Markus Barak, Hornung Gil, Balint-Lahat Nora, Yosepovich Ady, Hout-Siloni Goni, Jacob-Hirsch Jasmine, Sklair-Levy Miri, Friedman Eitan, Barshack Iris, Kaufman Bella, Gal-Yam Einav Nili, Paluch-Shimon Shani
Abstract excerpt
Abnormal molecular processes occurring throughout the genome leave distinct somatic mutational patterns termed mutational signatures. Exploring the associations between mutational signatures and clinicopathological features can unravel potential mechanisms driving tumorigenic processes. We analyzed whole genome sequencing (WGS) data of tumor and peripheral blood samples from 37 primary breast cancer (BC) patients...
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