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Article

Longitudinal within-host evolution of HIV Nef-mediated CD4, HLA and SERINC5 downregulation activity: a case study.

Retrovirology - 9 Jan 2020

Sudderuddin Hanwei, Kinloch Natalie N, Jin Steven W, Miller Rachel L, Jones Bradley R, Brumme Chanson J, Joy Jeffrey B, Brockman Mark A, Brumme Zabrina L

Abstract excerpt

The HIV accessory protein Nef downregulates the viral entry receptor CD4, the Human Leukocyte Antigen (HLA)-A and -B molecules, the Serine incorporator 5 (SERINC5) protein and other molecules from the infected cell surface, thereby promoting viral infectivity, replication and immune evasion. The nef locus also represents one of the most genetically variable regions in the HIV genome, and nef sequences undergo...

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Share to CD4 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to HIV Infections

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Share to nef Gene Products, Human Immunodeficiency Virus

Source

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Identifiers

PMID: 31918727
DOI: 10.1186/s12977-019-0510-1
PMCID: PMC6953280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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