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Mechanisms of Immune Evasion in HIV-1: The Role of Virus-Host Protein Interactions

16 May 2025

Abstract excerpt

This review explores the mechanisms by which Human Immunodeficiency Virus type 1 (HIV-1) regulatory proteins manipulate host cellular pathways to promote viral replication and immune evasion. Key viral proteins, such as Nef, Vpu, Vif, Vpr, and Env, disrupt immune defenses by downregulating surface molecules such as CD4 (Cluster of Differentiation 4) and Major Histocompatibility Complex (MHC) class I, degrading...

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PMID: 40699766
DOI: 10.3390/cimb47050367

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