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Article

An Amino Acid Polymorphism within the HIV-1 Nef Dileucine Motif Functionally Uncouples Cell Surface CD4 and SERINC5 Downregulation.

Journal of virology - 26 Jul 2021

Mumby Mitchell J, Johnson Aaron L, Trothen Steven M, Edgar Cassandra R, Gibson Richard, Stathopulos Peter B, Arts Eric J, Dikeakos Jimmy D

Abstract excerpt

Serine incorporator 5 (SERINC5) reduces the infectivity of progeny HIV-1 virions by incorporating into the outer host-derived viral membrane during egress. To counter SERINC5, the HIV-1 accessory protein Nef triggers SERINC5 internalization by engaging the adaptor protein 2 (AP-2) complex using the [D/E]xxxL[L/I]167 Nef dileucine motif. Nef also engages AP-2 via its dileucine motif to downregulate the CD4...

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Share to Amino Acid Motifs
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to nef Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 34037423
DOI: 10.1128/JVI.00588-21
PMCID: PMC8312866

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