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Article

Maintenance of Nef-mediated modulation of major histocompatibility complex class I and CD4 after sexual transmission of human immunodeficiency virus type 1.

Journal of virology - 1 May 2007

Noviello C M, Pond S L Kosakovsky, Lewis M J, Richman D D, Pillai S K, Yang O O, Little S J, Smith D M, Guatelli J C

Abstract excerpt

Viruses encounter changing selective pressures during transmission between hosts, including host-specific immune responses and potentially varying functional demands on specific proteins. The human immunodeficiency virus type 1 Nef protein performs several functions potentially important for successful infection, including immune escape via down-regulation of class I major histocompatibility complex (MHC-I) and...

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Share to CD4 Antigens
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Gene Products, nef

Share to Genes, MHC Class I

Share to Likelihood Functions

Share to nef Gene Products, Human Immunodeficiency Virus

Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 17329339
DOI: 10.1128/JVI.01793-06
PMCID: PMC1900175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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