Article

Proteasomal degradation of human SERINC4: a potent host anti-HIV-1 factor that is antagonized by Nef

2020-12-07

Abstract excerpt

The serine incorporator (SERINC) protein family has five paralogous members with 9-11 transmembrane domains. SERINC5 is a potent host restriction factor and antagonized by HIV-1 Nef and two other retroviral accessory proteins via the lysosomal degradation pathway. Here, we investigated human SERINC4 expression and antiviral mechanisms. Unlike its four paralogs, human SERINC4 is subjected to proteasome-mediated tur...

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Literature Corpus work: 648bc4ae-3cd7-551c-8857-aa73bd01b803
DOI: 10.1101/2020.12.07.414888

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