Article
Nef Obtained from Individuals with HIV-1 Vary in Their Ability to Antagonize SERINC3- and SERINC5-Mediated HIV-1 Restriction.
Viruses - 6 Mar 2021
Kruize Zita, van Nuenen Ad C, van Wijk Stan W, Girigorie Arginell F, van Dort Karel A, Booiman Thijs, Kootstra Neeltje A
Abstract excerpt
Nef is a multifunctional viral protein that has the ability to downregulate cell surface molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as recently shown, also members of the serine incorporator family (SERINC). Here, we analyzed the impact of naturally occurring mutations in HIV-1 Nef on its ability to counteract SERINC restriction and the clinical course of infection. HIV-1...
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