Article
Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2020
Kľučková Katarína, Thakker Alpesh, Vettore Lisa, Escribano-Gonzalez Cristina, Hindshaw Rebecca L, Tearle Jacqueline L E, Goncalves Judith, Kaul Baksho, Lavery Gareth G, Favier Judith, Tennant Daniel A
Abstract excerpt
Mutations in succinate dehydrogenase (SDH) lead to the development of tumors in a restricted subset of cell types, including chromaffin cells and paraganglia. The molecular basis for this specificity is currently unknown. We show that loss of SDH activity in a chromaffin cell model does not perturb complex I function, retaining the ability to oxidize NADH within the electron transport chain. This activity...
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