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Article

Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma.

Endocrine-related cancer - 1 Jun 2014

Vicha Ales, Taieb David, Pacak Karel

Abstract excerpt

Warburg's metabolic hypothesis is based on the assumption that a cancer cell's respiration must be under attack, leading to its damage, in order to obtain increased glycolysis. Although this may not apply to all cancers, there is some evidence proving that primarily abnormally functioning mitochondrial complexes are indeed related to cancer development. Thus, mutations in complex II (succinate dehydrogenase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24500761
DOI: 10.1530/ERC-13-0398
PMCID: PMC4016161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma.PMID 24500761Read ↗

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Metabolic Effects of Succinate Dehydrogenase Loss in CancerSemantic proximity Read ↗

The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in TumorigenesisSemantic proximity Read ↗

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The connection between tricarboxylic acid cycle enzyme mutations and pseudohypoxic signaling in pheochromocytoma and paraganglioma.Semantic proximity Read ↗

Metabolic changes in cancer: beyond the Warburg effect.Semantic proximity Read ↗

Succinate-to-fumarate ratio as a new metabolic marker to detect the presence of SDHB/D-related paraganglioma: initial experimental and ex vivo findings.Semantic proximity Read ↗

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Back to Biochemistry: Evaluation for and Prognostic Significance of SDH Mutations in Paragangliomas and Pheochromocytomas.Semantic proximity Read ↗

Back to Biochemistry: Evaluation for and Prognostic Significance of SDH Mutations in Paragangliomas and Pheochromocytomas.Semantic proximity Read ↗

15 YEARS OF PARAGANGLIOMA: Genetics and mechanism of pheochromocytoma–paraganglioma syndromes characterized by germline SDHB and SDHD mutationsSemantic proximity Read ↗

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