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Metabolic Effects of Succinate Dehydrogenase Loss in Cancer

1 Jul 2025

Abstract excerpt

ABSTRACT Succinate dehydrogenase (SDH) is both Complex II in the electron transport chain (ETC) and a key metabolic enzyme in the tricarboxylic acid cycle. SDH is a heterotetrameric enzyme consisting of four subunits SDHA, SDHB, SDHC, and SDHD, all encoded in the nuclear genome. In addition, the SDH complex requires two assembly factors, SDHAF1 and SDHAF2, which are required for assembly of SDHA and SDHB onto the...

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PMID: 40685935
DOI: 10.1002/jcp.70066

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