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Article

Hypothesis: Why Different Types of SDH Gene Variants Cause Divergent Tumor Phenotypes.

Genes - 7 Jun 2022

Bayley Jean-Pierre, Devilee Peter

Abstract excerpt

Despite two decades of paraganglioma-pheochromocytoma research, the fundamental question of how the different succinate dehydrogenase (SDH)-related tumor phenotypes are initiated has remained unanswered. Here, we discuss two possible scenarios by which missense (hypomorphic alleles) or truncating (null alleles) SDH gene variants determine clinical phenotype. Dysfunctional SDH is a major source of reactive oxygen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35741787
DOI: 10.3390/genes13061025
PMCID: PMC9222429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Hypothesis: Why Different Types of SDH Gene Variants Cause Divergent Tumor Phenotypes.PMID 35741787Read ↗

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Functional consequences of succinate dehydrogenase mutations.Semantic proximity Read ↗

SDHB variant type impacts phenotype and malignancy in pheochromocytoma-paraganglioma.Semantic proximity Read ↗

Variant type is associated with disease characteristics in SDHB, SDHC and SDHD-linked phaeochromocytoma–paragangliomaSemantic proximity Read ↗

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A review of the tumour spectrum of germline succinate dehydrogenase gene mutations: Beyond phaeochromocytoma and paraganglioma.Semantic proximity Read ↗

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SDHA is a tumor suppressor gene causing paraganglioma.Semantic proximity Read ↗

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