Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas.

doi:10.3389/fendo.2021.589451

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Article

Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas.

Frontiers in endocrinology - 1 Jan 2021

Matlac Dieter M, Hadrava Vanova Katerina, Bechmann Nicole, Richter Susan, Folberth Julica, Ghayee Hans K, Ge Guang-Bo, Abunimer Luma, Wesley Robert, Aherrahrou Redouane, Dona Margo, Martínez-Montes Ángel M, Calsina Bruna, Merino Maria J, Schwaninger Markus, Deen Peter M T, Zhuang Zhengping, Neuzil Jiri, Pacak Karel, Lehnert Hendrik, Fliedner Stephanie M J

Abstract excerpt

Paragangliomas and pheochromocytomas (PPGLs) are chromaffin tumors associated with severe catecholamine-induced morbidities. Surgical removal is often curative. However, complete resection may not be an option for patients with succinate dehydrogenase subunit A-D (SDHx) mutations. SDHx mutations are associated with a high risk for multiple recurrent, and metastatic PPGLs. Treatment options in these cases are...

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PMID: 33776908
DOI: 10.3389/fendo.2021.589451
PMCID: PMC7994772

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