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Genetic, epigenetic and biochemical regulation of succinate dehydrogenase function

13 Aug 2019

Abstract excerpt

Succinate dehydrogenase (SDH), complex II or succinate:quinone oxidoreductase (SQR) is a crucial enzyme involved in both the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS), the two primary metabolic pathways for generating ATP. Impaired function of SDH results in deleterious disorders from cancer to neurodegeneration. SDH function is tailored to meet the energy demands in different cell...

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PMID: 31408429
DOI: 10.1515/hsz-2019-0264

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