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Article

Succinate-to-fumarate ratio as a new metabolic marker to detect the presence of SDHB/D-related paraganglioma: initial experimental and ex vivo findings.

Endocrinology - 1 Jan 2014

Lendvai Nikoletta, Pawlosky Robert, Bullova Petra, Eisenhofer Graeme, Patocs Attila, Veech Richard L, Pacak Karel

Abstract excerpt

Pheochromocytomas (PHEOs) and paragangliomas (PGLs; extra-adrenal tumors) are rare neuroendocrine chromaffin cell tumors with a hereditary background in about 30%-35%. Those caused by succinate dehydrogenase subunit B (SDHB) germline mutations are associated with a high metastatic potential and ultimately higher patient mortality. Succinate dehydrogenase converts succinate to fumarate, uniquely linking the Krebs...

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Source

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Identifiers

PMID: 24189137
DOI: 10.1210/en.2013-1549
PMCID: PMC5398636

Genes

SDHB
SDHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Succinate-to-fumarate ratio as a new metabolic marker to detect the presence of SDHB/D-related paraganglioma: initial experimental and ex vivo findings.PMID 24189137Read ↗

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