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Article

Multisite EGFR phosphorylation is regulated by adaptor protein abundances and dimer lifetimes.

Molecular biology of the cell - 19 Mar 2020

Salazar-Cavazos Emanuel, Nitta Carolina Franco, Mitra Eshan D, Wilson Bridget S, Lidke Keith A, Hlavacek William S, Lidke Diane S

Abstract excerpt

Differential epidermal growth factor receptor (EGFR) phosphorylation is thought to couple receptor activation to distinct signaling pathways. However, the molecular mechanisms responsible for biased signaling are unresolved due to a lack of insight into the phosphorylation patterns of full-length EGFR. We extended a single-molecule pull-down technique previously used to study protein-protein interactions to allow...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31913761
DOI: 10.1091/mbc.E19-09-0548
PMCID: PMC7202077

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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