Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantitative proteomics and phosphoproteomics reveal novel insights into complexity and dynamics of the EGFR signaling network

7 Oct 2008

Abstract excerpt

The epidermal growth factor receptor (EGFR/ErbB1/Her1) belongs to the ErbB family of receptor tyrosine kinases (RTKs) and is a key player in the regulation of cell proliferation, differentiation, survival, and migration. Overexpression and mutational changes of EGFR have been identified in a variety of human cancers and the regulation of EGFR signaling plays a critical role in tumor development and progression....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosylation and Glycoproteins Research
Share to HER2/EGFR in Cancer Research
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18846509
DOI: 10.1002/pmic.200800204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantitative proteomics and phosphoproteomics reveal novel insights into complexity and dynamics of the EGFR signaling networkPMID 18846509Read ↗

Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling.Semantic proximity Read ↗

Mining the tumor phosphoproteome for cancer markers.Semantic proximity Read ↗

The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification.Semantic proximity Read ↗

Dynamic EGFR interactomes reveal differential association of signaling modules with wildtype and Exon19-del EGFR in NSCLC cell lines.Semantic proximity Read ↗

Mass Spectrometry Mapping of Epidermal Growth Factor Receptor Phosphorylation Related to Oncogenic Mutations and Tyrosine Kinase Inhibitor SensitivitySemantic proximity Read ↗

The Role of Proteomics and Phosphoproteomics in the Discovery of Therapeutic Targets and Biomarkers in Acquired EGFR-TKI-Resistant Non-Small Cell Lung Cancer.Semantic proximity Read ↗

Epidermal growth factor receptor: Role in human cancerSemantic proximity Read ↗

ErbB Receptors and Cancer.Semantic proximity Read ↗

Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locationsSemantic proximity Read ↗

Signaling networks assembled by oncogenic EGFR and c-MetSemantic proximity Read ↗

Multisite EGFR phosphorylation is regulated by adaptor protein abundances and dimer lifetimes.Semantic proximity Read ↗

Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.