Oncogenic EGFR mutants differentially alter dimerization, adaptor protein engagement, and clathrin-mediated internalization.

Abstract excerpt

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase whose activation, clustering, and endocytic trafficking together regulate the duration and strength of downstream signaling. In non-small cell lung cancer (NSCLC), activating mutations such as exon 19 deletions (ex19del) and L858R drive oncogenesis, yet how these mutations alter receptor clustering and engagement with the endocytic...

Topics

• ErbB Receptors
• Humans
• Clathrin
• Mutation
• Protein Multimerization
• Endocytosis
• Lung Neoplasms