Article

A tyrosine kinase protein interaction map reveals targetable EGFR network oncogenesis in lung cancer

2020-07-03

Abstract excerpt

<h4>SUMMARY</h4> Signaling networks balance the activities of many physically interacting proteins and perturbations to this network influence downstream signaling, potentially leading to oncogenic states. Using affinity purification-mass spectrometry we defined this network for all 90 human tyrosine kinases revealing 1,463 mostly novel interactions between these key cancer proteins and diverse molecular complexe...

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Literature Corpus work: 51e5fd5f-7dd2-5789-87b2-6f57be8a6162
DOI: 10.1101/2020.07.02.185173

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