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Article

Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer's Disease Across Distinct Brain Regions.

Journal of proteome research - 2 Aug 2024

Odenkirk Melanie T, Zheng Xueyun, Kyle Jennifer E, Stratton Kelly G, Nicora Carrie D, Bloodsworth Kent J, Mclean Catriona A, Masters Colin L, Monroe Matthew E, Doecke James D, Smith Richard D, Burnum-Johnson Kristin E, Roberts Blaine R, Baker Erin S

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disease with a complex etiology influenced by confounding factors such as genetic polymorphisms, age, sex, and race. Traditionally, AD research has not prioritized these influences, resulting in dramatically skewed cohorts such as three times the number of Apolipoprotein E (APOE) ε4-allele carriers in AD relative to healthy cohorts. Thus, the resulting molecular...

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PMID: 38236019
DOI: 10.1021/acs.jproteome.3c00604
PMCID: PMC11255128

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