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Alzheimer's brains show inter-related changes in RNA and lipid metabolism

19 Jun 2017

Abstract excerpt

Alzheimer's disease (AD) involves changes in both lipid and RNA metabolism, but it remained unknown if these differences associate with AD's cognition and/or post-mortem neuropathology indices. Here, we report RNA-sequencing evidence of inter-related associations between lipid processing, cognition level, and AD neuropathology. In two unrelated cohorts, we identified pathway-enriched facilitation of lipid...

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PMID: 28630030
DOI: 10.1016/j.nbd.2017.06.008

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