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Article

The common promoter polymorphism rs11666254 downregulates FPR2/ALX expression and increases risk of sepsis in patients with severe trauma.

Critical care (London, England) - 6 Jul 2017

Zhang Han, Lu Yao, Sun Guixiang, Teng Fang, Luo Nian, Jiang Jianxin, Wen Aiqing

Abstract excerpt

BACKGROUND: Formyl peptide receptor 2-lipoxin receptor (FPR2/ALX) modulates the anti-inflammatory response and therefore may be a target for treating sepsis. The purpose of this study was to investigate the association between genetic variants of the FPR2/ALX gene and sepsis after severe trauma as well as to further analyze the functions of sepsis-related genetic polymorphisms. METHODS: Three tag...

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Source

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Identifiers

PMID: 28679406
DOI: 10.1186/s13054-017-1757-3
PMCID: PMC5499024

Genes

FPR2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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