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Article

Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans.

Human molecular genetics - 15 Mar 2015

Ferguson Jane F, Meyer Nuala J, Qu Liming, Xue Chenyi, Liu Yichuan, DerOhannessian Stephanie L, Rushefski Melanie, Paschos Georgios K, Tang Soonyew, Schadt Eric E, Li Mingyao, Christie Jason D, Reilly Muredach P

Abstract excerpt

Fever predicts clinical outcomes in sepsis, trauma and during cardiovascular stress, yet the genetic determinants are poorly understood. We used an integrative genomics approach to identify novel genomic determinants of the febrile response to experimental endotoxemia. We highlight multiple integrated lines of evidence establishing the clinical relevance of this novel fever locus. Through genome-wide association...

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Share to Chromosomes, Human, Pair 7
Share to Fever

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Lipopolysaccharides

Share to Regulatory Elements, Transcriptional

Share to Sepsis

Share to Stress, Physiological

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Source

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Identifiers

PMID: 25416278
DOI: 10.1093/hmg/ddu589
PMCID: PMC4351381

Genes

PSPH
SUMF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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