Article
Identification of haplotype tag SNPs within the whole myeloid differentiation 2 gene and their clinical relevance in patients with major trauma.
Shock (Augusta, Ga.) - 1 Apr 2012
Zeng Ling, Zhang An-qiang, Gu Wei, Zhou Jian, Zhang Lian-yang, Du Ding-yuan, Zhang Mao, Wang Hai-yan, Jiang Jian-xin
Abstract excerpt
Myeloid differentiation 2 (MD-2) plays a critical role in orchestrating the innate immune response and the development of sepsis and subsequent organ dysfunction after trauma. The objectives of this prospective study were to identify haplotype tag single-nucleotide polymorphisms (htSNPs) within the entire MD-2 gene and to investigate their clinical relevance in patients with major trauma. A total of 726 patients...
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