Article
Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma.
Cancer cell - 8 Jan 2024
Sun Yunfan, Wu Pin, Zhang Zefan, Wang Zejian, Zhou Kaiqian, Song Minfang, Ji Yuan, Zang Fenglin, Lou Limu, Rao Keqiang, Wang Pengxiang, Gu Yutong, Gu Jie, Lu Binbin, Chen Limeng, Pan Xiuqi, Zhao Xiaojing, Peng Lihua, Liu Dongbing, Chen Xiaofang, Wu Kui, Lin Penghui, Wu Liang, Su Yulin, Du Min, Hou Yingyong, Yang Xinrong, Qiu Shuangjian, Shi Yinghong, Sun Huichuan, Zhou Jian, Huang Xingxu, Peng David H, Zhang Liye, Fan Jia
Abstract excerpt
Comprehensive molecular analyses of metastatic hepatocellular carcinoma (HCC) are lacking. Here, we generate multi-omic profiling of 257 primary and 176 metastatic regions from 182 HCC patients. Primary tumors rich in hypoxia signatures facilitated polyclonal dissemination. Genomic divergence between primary and metastatic HCC is high, and early dissemination is prevalent. The remarkable neoantigen intratumor...
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