Article
Comprehensive analysis of tumour mutation burden and the immune microenvironment in hepatocellular carcinoma.
International immunopharmacology - 1 Dec 2020
Xie Fucun, Bai Yi, Yang Xu, Long Junyu, Mao Jinzhu, Lin Jianzhen, Wang Dongxu, Song Yang, Xun Ziyu, Huang Hanchan, Yang Xiaobo, Zhang Lei, Mao Yilei, Sang Xinting, Zhao Haitao
Abstract excerpt
Tumour mutation burden (TMB) and the immune microenvironment (IME) are reportedly associated with immunotherapy responses, but this relationship remains unclear in hepatocellular carcinoma (HCC). We classified HCC patients in the liver hepatocellular carcinoma cohort from The Cancer Genome Atlas into low- and high-TMB groups and evaluated differences in immune infiltrates. Additionally, differentially expressed...
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