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Article

Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

11 Jan 2021

Abstract excerpt

The clinical relevance of immune landscape intratumoural heterogeneity (immune-ITH) and its role in tumour evolution remain largely unexplored. Here, we uncover significant spatial and phenotypic immune-ITH from multiple tumour sectors and decipher its relationship with tumour evolution and disease progression in hepatocellular carcinomas (HCC). Immune-ITH is associated with tumour transcriptomic-ITH, mutational...

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PMID: 33431814
DOI: 10.1038/s41467-020-20171-7

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