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Article

Multi-omics profiling reveals divergent biology and liver microenvironment in HCC of metastatic and de novo origin.

Molecular cancer - 6 Mar 2026

Boot Gina F, Haak Fabian, Coto-Llerena Mairene, Boldanova Tuyana, Dazert Eva, Sedlaczek Philip, Rosenberger George, Esposito Cinzia, Ercan Caner, Wieland Stefan, Renne Salvatore Lorenzo, Benjak Andrej, Matter Matthias S, Di Tommaso Luca, Hall Michael N, Terracciano Luigi M, Heim Markus H, Piscuoglio Salvatore, Ng Charlotte K Y

Abstract excerpt

BACKGROUND: Multifocal hepatocellular carcinoma (mfHCC) arises via intrahepatic metastasis (IM) or multicentric occurrence (MO), each with distinct biological behavior and clinical implications, though mfHCC origin is rarely assessed in clinical practice. We aimed to characterize the clinicopathological and molecular features of IM-HCC, MO-HCC, and their surrounding non-tumor liver (NTL) tissues using multi-omics...

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Topics

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Share to Carcinoma, Hepatocellular
Share to Exome Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

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Source

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Identifiers

PMID: 41792761
DOI: 10.1186/s12943-026-02604-x
PMCID: PMC13078022

Genes

BUB1
MYC
NUF2
PTEN
SOX2
TGFA
TTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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