Article

Divergent malignant evolution converges on shared immunosuppressive ecosystems through tumor-intrinsic TMED2–ADAR1-dependent complement signalling in multifocal hepatocellular carcinoma

2026-04-23

Abstract excerpt

<h4>Background</h4> Multifocal hepatocellular carcinoma (HCC) comprises spatially separated tumor foci with distinct evolutionary trajectories, posing a major therapeutic challenge. Whether divergent lesions retain shared immune-evasion mechanisms beyond lesion-specific heterogeneity and offer cross-focal therapeutic opportunities remains unknown. <h4>Objective</h4> To resolve malignant and microenvironmental he...

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Literature Corpus work: 386aef24-f815-5db1-bb40-f829eb12049c
DOI: 10.64898/2026.04.21.719788

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