Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic and the tumor microenvironment heterogeneity in multifocal hepatocellular carcinoma

12 Dec 2024

Abstract excerpt

BACKGROUND AND AIMS: Ambiguous understanding of tumors and tumor microenvironments (TMEs) hinders accurate diagnosis and available treatment for multifocal hepatocellular carcinoma (HCC) covering intrahepatic metastasis (IM) and multicentric occurrence (MO). Here, we characterized the diverse TMEs of IM and MO identified by whole-exome sequencing at single-cell resolution. APPROACH AND RESULTS: We performed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ferroptosis and cancer prognosis
Share to Hepatocellular Carcinoma Treatment and Prognosis
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39666875
DOI: 10.1097/hep.0000000000001191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic and the tumor microenvironment heterogeneity in multifocal hepatocellular carcinomaPMID 39666875Read ↗

Multi-omics profiling reveals divergent biology and liver microenvironment in HCC of metastatic and de novo origin.Semantic proximity Read ↗

Deciphering the heterogeneous niche in the tumor progression of hepatocellular carcinoma: a Spatial single-cell landscape and multi-omics atlas analysisSemantic proximity Read ↗

Integrated Multi-Omics Landscape of Liver Metastases.Semantic proximity Read ↗

Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinoma.Semantic proximity Read ↗

The Endless Sources of Hepatocellular Carcinoma HeterogeneitySemantic proximity Read ↗

Molecular evolution in different subtypes of multifocal hepatocellular carcinomaSemantic proximity Read ↗

Deciphering Tumor Heterogeneity in Hepatocellular Carcinoma (HCC)—Multi-Omic and Singulomic ApproachesSemantic proximity Read ↗

Divergent malignant evolution converges on shared immunosuppressive ecosystems through tumor-intrinsic TMED2–ADAR1-dependent complement signalling in multifocal hepatocellular carcinomaSemantic proximity Read ↗

Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity.Semantic proximity Read ↗

The Influence of Immune Heterogeneity on the Effectiveness of Immune Checkpoint Inhibitors in Multifocal Hepatocellular Carcinomas.Semantic proximity Read ↗

Single-cell Multi-omics reveal heterogeneity and metastasis potential in different liver cancer cell linesSemantic proximity Read ↗

Comprehensive molecular and immunological characterization of hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.