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Article

The Influence of Immune Heterogeneity on the Effectiveness of Immune Checkpoint Inhibitors in Multifocal Hepatocellular Carcinomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2020

Huang Manling, He Minghui, Guo Yu, Li Heping, Shen Shunli, Xie Yubin, Li Xiaoxing, Xiao Han, Fang Lujing, Li Dongming, Peng Baogang, Liang Lijian, Yu Jun, Kuang Ming, Xu Lixia, Peng Sui

Abstract excerpt

PURPOSE: Immune checkpoint inhibitor therapy is emerging as the promising option for patients with advanced hepatocellular carcinoma. We aimed to investigate the heterogeneity of different tumor nodules of the same patient with multifocal hepatocellular carcinomas in response to immunotherapy and its molecular mechanisms. EXPERIMENTAL DESIGN: We attained 45 surgical tumor samples including 33 small and 12 large...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32527942
DOI: 10.1158/1078-0432.CCR-19-3840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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