Article
From Genotype to Phenotype: Cytochrome P450 2D6-Mediated Drug Clearance in Humans.
Molecular pharmaceutics - 6 Mar 2017
Gao Jie, Tian Xin, Zhou Jun, Cui Ming-Zhu, Zhang Hai-Feng, Gao Na, Wen Qiang, Qiao Hai-Ling
Abstract excerpt
How genotypic variation results in phenotypic differences is still a challenge for biology. In the field of drug metabolism, the means by which specific cytochrome P4502D6 (CYP2D6) genotypes yield different phenotypes at various levels (molecular, cellular, and organismal) is an important question, as differences in CYP2D6 activity can contribute to adverse drug reactions. Herein, the genotype of CYP2D6 was...
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