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Article

Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors.

The Journal of pharmacology and experimental therapeutics - 1 Jan 2017

Tanner Julie-Anne, Prasad Bhagwat, Claw Katrina G, Stapleton Patricia, Chaudhry Amarjit, Schuetz Erin G, Thummel Kenneth E, Tyndale Rachel F

Abstract excerpt

Cytochrome P450 2A6 CYP2A6: metabolizes several clinically relevant substrates, including nicotine, the primary psychoactive component in cigarette smoke. Smokers vary widely in their rate of inactivation and clearance of nicotine, altering numerous smoking phenotypes. We aimed to characterize independent and shared impact of genetic and nongenetic sources of variation in CYP2A6 mRNA, protein, and enzyme activity...

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Share to Cytochrome P-450 CYP2A6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27815364
DOI: 10.1124/jpet.116.237594
PMCID: PMC5193072

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POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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